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First presentation of our bovine lung organoids at the scientific AVIESAN meeting "From 3D Culture to Organoids" co-organized by ITMO 'Health Technologies' and ITMO 'Cell Biology, development and evolution' December the 2nd 2019 in Paris.

Recent advances in isolating epithelial progenitor cells, as well as defining niche factors important for lung development, have led to the establishment of in vitro 3D lung culture system called pulmonary (lung) organoids. Epithelial stem and progenitor cells are cultured in an extracellular matrix supplemented with either a mixture of growth factors or stromal cells. Cells self-organize into complex structure and recapitulate various features of the lung including heterogeneous cell composition, spatial organization and polarization, mucus production and ciliary activity. The most attractive advantages of lung organoid cultures is that they allow for the expansion of lung stem cell populations and the induction of differentiated cells from very limited amounts of starting material. In addition, it provides a more physiologically relevant culture system, particularly for the distal lung. These models have become valuable tools for exploring pulmonary physiology and pathologies such as infectious diseases: they allow to better understand and characterize host-pathogen interactions, to predict the virulence of respiratory pathogens and to screen anti-viral drugs.

The work presented by F Archer (IVPC) and Jérôme Sohier (Mateis Insa Lyon) "Respiratory Organoids and hydrogels" at the Aviesan meeting is supported by ANR funding EpiLung.