Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free:

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site:, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Google Analytics

Targeted advertising cookies


The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at or by post at:

24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal Lyon 1 EPHE

Home page

Our research projects

From mosquitoes to mammals: a better understanding of alphaviruses transmission and host response.

We are recently  witnessing a resurgence or emergence of new infectious diseases of great concern for human public health, as well as for animal health. Many of these diseases are caused by viruses transmitted by biting insects, or arthropods : the so called "arboviruses". Many arboviruses, infecting both humans and animals, and especially livestock, may cause zoonoses, with dramatic health and economic impact in some parts of the world.

Some of these viruses have expanded their geographical distribution, particularly through the spread of their insect vector, the mosquito. The entry of the flavivirus Zika in Brazil for the first time on the American continent in 2015, as well as the Chikungunya alphavirus at the end of 2014 in the Antilles, are recent examples. It has also been shown that these viruses can adapt to new vectors, as did Chikungunya during the 2007 Indian Ocean epidemic, initially transmitted by Aedes Aegypti and later by Aedes Albopictus (the "tiger mosquito "). Finally, the pathologies induced by these infections are also very variable, ranging from mild symptoms to serious chronic complications.

Our team is mainly interested in alphaviruses, for which there is currently no vaccine or specific treatment. By studying their mode of infection in mammals and insects, in vitro and in vivo, our project aims at identifying and understanding the factors responsible for the pathogenicity or resistance of the host:

  • Which are the host factors involved in virus entry, its tissue tropism and its interspecies transmission? To answer this question we use for example whole genome CRISPR/Cas9 screens, analyzed by NGS (Sequencing Platform - IGFL).
  • What is the role of host response, such as cell death, in the in vivo viral propagation and the difference in pathogenicity between species? In addition to human and mosquitoes cell models, we also use Drosophila as an in vivo model to study different cell death pathways involvement, as it is a powerfull genetic tool, easy to manipulate (in collaboration with B Mollereau, LBMC, ENS Lyon).   



Grant :    

Collaboration with the Institut Pasteur of Shanghai

IPS, Chinese Academy of Science
Read more